I admit I am being a bit of a slacker on keeping this up to date - but you know how to find me in Pubmed. However, this LemBix thing is working out OK - 51 papers and counting
What does “Disruptive” mean? Thoughts on the NIH SCI 2020 meeting. Lemmon VP Neural Regen Res 14(9):1527-1529. DOI:10.4103/1673-5374.255969
Validation study of neurotrophin-3-releasing chitosan facilitation of neural tissue generation in the severely injured adult rat spinal cord. Oudega M, Hao P, Shang J, Haggerty AE, Wang Z, Sun J, Liebl DJ, Shi Y, Cheng L, Duan H, Sun YE, Li X, Lemmon VP. Exp Neurol. 2019 Feb;312:51-62. doi: 10.1016/j.expneurol.2018.11.003. Epub 2018 Nov 22. PMID: 30471251. THIS PROJECT WAS FASCINATING AND A LOT OF WORK. HOPEFULLY IT IS USEFUL. PLEASE SEE THE COMMENTARY BY SCHAFFRAN AND BRADKE.
The effect of Jun dimerization on neurite outgrowth and motif binding. Danzi MC, Mehta ST, Dulla K, Zunino G, Cooper DJ, Bixby JL, Lemmon VP. Mol Cell Neurosci. 2018 Oct;92:114-127. doi: 10.1016/j.mcn.2018.08.001. Epub 2018 Aug 3. PMID: 30077771
Scaffold Ranking and Positional Scanning Identify Novel Neurite Outgrowth Promoters with Nanomolar Potency. Al-Ali H, Debevec G, Santos RG, Houghten RA, Davis JC, Nefzi A, Lemmon VP, Bixby JL, Giulianotti MA. ACS Med Chem Lett. 2018 Sep 24;9(10):1057-1062. doi: 10.1021/acsmedchemlett.8b00425. eCollection 2018 Oct 11. PMID: 30344917
THIS PAPER IS CRAZY! WE SCREENED OVER 400 MILLION COMPOUNDS ON PRIMARY NEURONS! WE DISCOVERED SOME VERY POTENT NEURITE GROWTH PROMOTERS.
Injury type-dependent differentiation of NG2 glia into heterogeneous astrocytes. Amber R. Hackett, Stephanie L. Yahn, Kirill Lyapichev, Angela Dajnoki, Do-Hun Lee, Mario Rodriguez, Natasha Cammer, Ji Pak, Saloni T. Mehta, Olaf Bodamer, Vance P. Lemmon, Jae K. Lee https://doi.org/10.1016/j.expneurol.2018.07.001
The Assay Guidance Manual: Quantitative Biology and Pharmacology in Preclinical Drug Discovery. Coussens NP, Sittampalam GS, Guha R, Brimacombe K, Grossman A, Chung TDY, Weidner JR, Riss T, Trask OJ, Auld D, Dahlin JL, Devanaryan V, Foley TL, McGee J, Kahl SD, Kales SC, Arkin M, Baell J, Bejcek B, Gal-Edd N, Glicksman M, Haas JV, Iversen PW, Hoeppner M, Lathrop S, Sayers E, Liu H, Trawick B, McVey J, Lemmon VP, Li Z, McManus O, Minor L, Napper A, Wildey MJ, Pacifici R, Chin WW, Xia M, Xu X, Lal-Nag M, Hall MD, Michael S, Inglese J, Simeonov A, Austin CP. Clin Transl Sci. 2018 Jun 7. doi: 10.1111/cts.12570. PMID: 29877628
Can chromatin accessibility be exploited for axon regeneration? Danzi MC, O'Neill N, Bixby JL, Lemmon VP. Dev Neurobiol. 2018 Apr 17. doi: 10.1002/dneu.22598. Review. PMID: 29664188
Reactive oxygen species regulate axonal regeneration through the release of exosomal NADPH oxidase 2 complexes into injured axons. Hervera A, De Virgiliis F, Palmisano I, Zhou L, Tantardini E, Kong G, Hutson T, Danzi MC, Perry RB, Santos CXC, Kapustin AN, Fleck RA, Del Río JA, Carroll T, Lemmon V, Bixby JL, Shah AM, Fainzilber M, Di Giovanni S. Nat Cell Biol. 2018 Mar;20(3):307-319. doi: 10.1038/s41556-018-0039-x. Epub 2018 Feb 12. Erratum in: Nat Cell Biol. 2018 Mar 8; PMID: 29434374
Region specific knock-out reveals distinct roles of chromatin modifiers in adult neurogenic niches. Rhodes CT, Zunino G, Huang SA, Cardona SM, Cardona AE, Berger MS, Lemmon VP, Lin CA. Cell Cycle. 2018;17(3):377-389. doi: 10.1080/15384101.2018.1426417. PMID: 29433384
High Content Screening of Mammalian Primary Cortical Neurons. Motti D, Blackmore M, Bixby JL, Lemmon VP. Methods Mol Biol. 2018;1683:293-304. doi: 10.1007/978-1-4939-7357-6_17 PMID: 29082499
3D Visualization of Individual Regenerating Retinal Ganglion Cell Axons Reveals Surprisingly Complex Growth Paths. Bray ER, Noga M, Thakor K, Wang Y, Lemmon VP, Park KK, Tsoulfas P. eNeuro. 2017 Aug 29;4(4). pii: ENEURO.0093-17.2017. doi: 10.1523/ENEURO.0093-17.2017. eCollection 2017 Jul-Aug. PMID: 28856242
Stress Increases Peripheral Axon Growth and Regeneration through Glucocorticoid Receptor-Dependent Transcriptional Programs. Lerch JK, Alexander JK, Madalena KM, Motti D, Quach T, Dhamija A, Zha A, Gensel JC, Webster Marketon J, Lemmon VP, Bixby JL, Popovich PG. eNeuro. 2017 Aug 21;4(4). pii: ENEURO.0246-17.2017. doi: 10.1523/ENEURO.0246-17.2017. eCollection 2017 Jul-Aug. PMID: 28828403
Optic nerve regeneration in mammals: Regenerated or spared axons? Fischer D, Harvey AR, Pernet V, Lemmon VP, Park KK. Exp Neurol. 2017 Jul 14. pii: S0014-4886(17)30183-8. doi: 10.1016/j.expneurol.2017.07.008. Review. PMID: 28716559
Identification of miRNAs involved in DRG neurite outgrowth and their putative targets. Motti D, Lerch JK, Danzi MC, Gans JH, Kuo F, Slepak TI, Bixby JL, Lemmon VP. FEBS Lett. 2017 Jun 19. doi: 10.1002/1873-3468.12718. PMID: 28626869
The mTOR substrate S6 Kinase 1 (S6K1) is a negative regulator of axon regeneration and a potential drug target for Central Nervous System injury. Al-Ali H, Ding Y, Slepak T, Wu W, Sun Y, Martinez Y, Xu XM, Lemmon VP, Bixby JL. J Neurosci. 2017 Jun 16. pii: 0931-17. doi: 10.1523/JNEUROSCI.0931-17.2017. PMID: 28626016
Genetically modifying transcription factors to promote CNS axon regeneration. Mehta ST, Bixby JL, Lemmon VP. Neural Regen Res. 2017 May;12(5):737-738. doi: 10.4103/1673-5374.206637. No abstract available.PMID: 28616023
Phenotypic screening with primary neurons to identify drug targets for regeneration and degeneration. Cooper DJ, Zunino G, Bixby JL, Lemmon VP. Mol Cell Neurosci. 2017 Apr;80:161-169. doi: 10.1016/j.mcn.2016.07.001. Epub 2016 Jul 18. Review. PMID: 27444126
Developing a data sharing community for spinal cord injury research. Callahan A, Anderson KD, Beattie MS, Bixby JL, Ferguson AR, Fouad K, Jakeman LB, Nielson JL, Popovich PG, Schwab JM, Lemmon VP; FAIR Share Workshop Participants.
Exp Neurol. 2017 May 30. pii: S0014-4886(17)30137-1. Review. PMID: 28576567
Macrophage Transcriptional Profile Identifies Lipid Catabolic Pathways That Can Be Therapeutically Targeted after Spinal Cord Injury.
Zhu Y, Lyapichev K, Lee DH, Motti D, Ferraro NM, Zhang Y, Yahn S, Soderblom C, Zha J, Bethea JR, Spiller KL, Lemmon VP, Lee JK.
J Neurosci. 2017 Mar 37:2362-2376. PMID: 28130359
Gao H, Danzi MC, Choi CS, Taherian M, Dalby-Hansen C, Ellman DG, Madsen PM, Bixby JL, Lemmon VP, Lambertsen KL, Brambilla R. Opposing Functions of Microglial and Macrophagic TNFR2 in the Pathogenesis of Experimental Autoimmune Encephalomyelitis. Cell Rep. 2017 Jan 3;18(1):198-212. PMID: 2805224
Mehta ST, Luo X, Park KK, Bixby JL, Lemmon VP. Hyperactivated Stat3 boosts axon regeneration in the CNS. Exp Neurol. 2016 Apr 6. pii: S0014-4886(16)30049-8. PMID: 27060489
Callahan A, Abeyruwan SW, Al-Ali H, Sakurai K, Ferguson AR, Popovich PG, Shah NH, Visser U, Bixby JL, Lemmon VP. RegenBase: a knowledge base of spinal cord injury biology for translational research. Database (Oxford). 2016 Apr 7;2016. pii: baw040. Print 2016. PMID: 27055827
Luo X, Ribeiro M, Bray ER, Lee DH, Yungher BJ, Mehta ST, Thakor KA, Diaz F, Lee JK, Moraes CT, Bixby JL, Lemmon VP, Park KK. Enhanced Transcriptional Activity and Mitochondrial Localization of STAT3 Co-induce Axon Regrowth in the Adult Central Nervous System. Cell Rep. 2016 Mar 29. pii: S2211-1247(16)30285-6. doi: 10.1016/j.celrep.2016.03.029. [Epub ahead of print] PMID: 27050520
Danzi MC, Motti D, Avison DL, Bixby JL, Lemmon VP. Treatment with analgesics after mouse sciatic nerve injury does not alter expression of wound healing-associated genes. Neural Regen Res. 2016 Jan;11(1):144-9. doi: 10.4103/1673-5374.169637. PMID: 26981104
Peschansky VJ, Pastori C, Zeier Z, Motti D, Wentzel K, Velmeshev D, Magistri M, Bixby JL, Lemmon VP, Silva JP, Wahlestedt C. Changes in expression of the long non-coding RNA FMR4 associate with altered gene expression during differentiation of human neural precursor cells. Front Genet. 2015 Aug 10;6:263. doi: 10.3389/fgene.2015.00263.PMID: 26322075
Beckerman SR, Jimenez JE, Shi Y, Al-Ali H, Bixby JL, Lemmon VP. Phenotypic Assays to Identify Agents That Induce Reactive Gliosis: A Counter-Screen to Prioritize Compounds for Preclinical Animal Studies. Assay Drug Dev Technol. 2015 Jul 31.
Al-Ali H, Lee DH, Danzi MC, Nassif H, Gautam P, Wennerberg K, Zuercher B, Drewry DH, Lee JK, Lemmon VP, Bixby JL. Rational Polypharmacology: Systematically Identifying and Engaging Multiple Drug Targets To Promote Axon Growth. ACS Chem Biol. 2015 Jun 24. [Epub ahead of print] PMID: 26056718
C. Soderblom, D.H. Lee, A. Dawood, M. Carballosa, A.J. Santamaria, F.D. Benavides, S. Jergova1, R. Grumbles, C. Thomas, K.K. Park, J.D. Guest, V. Lemmon, J.K. Lee, P. Tsoulfas 3D imaging of axons in transparent spinal cords from rodents and non-human primates. eNeuro, Mar, 2015 DOI: 10.1523/ENEURO.0001-15.2015
Abeyruwan S, Vempati UD, Küçük-McGinty H, Visser U, Koleti A, Mir A, Sakurai K, Chung C, Bittker JA, Clemons PA, Brudz S, Siripala A, Morales AJ, Romacker M, Twomey D, Bureeva S, Lemmon V, Schürer SC. Evolving BioAssay Ontology (BAO): modularization, integration and applications. J Biomed Semantics. 2014 Jun 3;5(Suppl 1 Proceedings of the Bio-Ontologies Spec Interest G):S5. doi: 10.1186/2041-1480-5-S1-S5. eCollection 2014.
Lemmon VP, Ferguson AR, Popovich PG, Xu XM, Snow DM, Igarashi M, Beattie CE, Bixby JL; MIASCI Consortium. Minimum information about a spinal cord injury experiment: a proposed reporting standard for spinal cord injury experiments. J Neurotrauma. 2014 31:1354-61.
Abeyruwan S, Visser U, Bixby JL Facilitating transparency in spinal cord injury studies using data standards and ontologies. Neural Regeneration Research, 2014 9:6-7
Lerch, J, Martinez, Y. Bixby, JL. Lemmon VP, cJun promotes CNS axon growth. Mol Cell. Neuroscience 2014 Feb 9;59C:97-105. doi: 10.1016/j.mcn.2014.02.002. PMID: 24521823
Beurel E, Harrington LE, Buchser W, Lemmon V, Jope RS. Astrocytes Modulate the Polarization of CD4(+) T Cells to Th1 Cells. PLoS One. 2014 9:e86257. Doi 10.1371/journal.pone.0086257. . PMID: 24489707
Tonosaki M, Itoh K, Umekage M, Kishimoto T, Yaoi T, Lemmon VP, Fushiki S. L1cam Is Crucial for Cell Locomotion and Terminal Translocation of the Soma in Radial Migration during Murine Corticogenesis. PLoS One. 2014 9:e86186. doi: 10.1371/journal.pone.0086186. PMID: 24489698
Daftarian PM, Stone GW, Kovalski L, Kumar M, Vosoughi A, Urbieta M, Blackwelder P, Dikici E, Serafini P, Duffort S, Boodoo R, Rodríguez-Cortés A, Lemmon V, Deo S, Alberola J, Perez V, Daunert S, Ager AL. A targeted and adjuvanted nanocarrier lowers the effective dose of liposomal Amphotericin B and enhances adaptive immunity in murine cutaneous leishmaniasis. J Infect Dis. 2013 208:1914-22. doi: 10.1093/infdis/jit378. PMID: 23901083
Kuboyama T, Luo X, Park K, Blackmore MG, Tojima T, Tohda C, Bixby JL, Lemmon VP, Kamiguchi H. Paxillin phosphorylation counteracts proteoglycan-mediated inhibition of axon regeneration. Exp Neurol. 2013 248:157-169. doi: 10.1016/j.expneurol.2013.06.011. PMID: 23797153
Luo X, Salgueiro Y, Beckerman SR, Lemmon VP, Tsoulfas P, Park KK. Three-dimensional evaluation of retinal ganglion cell axon regeneration and pathfinding in whole mouse tissue after injury. Exp Neurol. 2013 Mar 16. [Epub ahead of print] PMID: 23510761.
Al-Ali H, Schürer SC, Lemmon VP, Bixby JL. Chemical Interrogation of the Neuronal Kinome Using a Primary Cell-Based Screening Assay. ACS Chem Biol. 2013 Mar 19. [Epub ahead of print] PMID: 23480631
Uma Vempati; Magdalena Przydzial; Saminda Abeyruwan; Kunie Sakurai; Caty Chung; Ubbo Visser; Vance Lemmon; Stephan Schürer. Formalization Annotation and Analysis of Diverse Drug and Probe Screening Assay Datasets using the BioAssay Ontology (BAO). PLoS One. 2012;7(11):e49198. doi: 10.1371/journal.pone.0049198. Epub 2012 Nov 14..
Kishimoto T, Itoh K, Umekage M, Tonosaki M, Yaoi T, Fukui K, Lemmon VP, Fushiki S. Downregulation of L1 perturbs neuronal migration and alters the expression of transcription factors in murine neocortex. J Neurosci Res. 2012 Oct 17. doi: 10.1002/jnr.23141.
Motti D, Bixby JL, Lemmon VP. MicroRNAs and Neuronal Development. Fetal Neurology. 2012 Aug 17. [Epub ahead of print]
Jo S, Kalló I, Bardóczi Z, Arrojo E Drigo R, Zeöld A, Liposits Z, Oliva A, Lemmon VP, Bixby JL, Gereben B, Bianco AC. Neuronal hypoxia induces hsp40-mediated nuclear import of type 3 deiodinase as an adaptive mechanism to reduce cellular metabolism. J Neurosci. 2012 32:8491-500. PMID: 22723689
Buchser WJ, Smith RP, Pardinas JR, Haddox CL, Hutson T, Moon L, Hoffman SR, Bixby JL, Lemmon VP. Peripheral nervous system genes expressed in central neurons induce growth on inhibitory substrates. PLoS One. 2012;7:e38101. PMID: 22701605
Dai J, Dalal JS, Thakar S, Henkemeyer M, Lemmon VP, Harunaga JS, Schlatter MC, Buhusi M, Maness PF. EphB regulates L1 phosphorylation during retinocollicular mapping. Mol Cell Neurosci. 2012 50:201-10.
Johnstone AL , Reierson GW, Smith RP, Goldberg JL, Lemmon VP, Bixby JL. A chemical genetic approach identifies piperazine antipsychotics as promoters of CNS neurite growth on inhibitory substrates Mol Cell Neurosci. 2012 Jun;50(2):125-35. doi: 10.1016/j.mcn.2012.04.008. Epub 2012 May 3.PMID: 22561309
Murray G. Blackmore, Zimei Wang, Jessica K. Lerch, Dario Motti, Yi Ping Zhang, Christopher B. Shields, Jae K. Lee, Jeffrey L. Goldberg, Vance P. Lemmon, and John L. Bixby. Kruppel-like Factor 7 engineered for transcriptional activation promotes axon regeneration in the adult corticospinal tract. Proc. Nat. Acad. Sci. 2012 109:7517-22.
Nelersa CM, Barreras H, Runko E, Ricard J, Shi Y, Glass SJ, Bixby JL, Lemmon VP, Liebl DJ. High-Content Analysis of Proapoptotic EphA4 Dependence Receptor Functions Using Small-Molecule Libraries. J Biomol Screen. 2012 Apr 6. [Epub ahead of print] PMID: 22492230
Slepak TI, Salay LD, Lemmon VP, Bixby JL. Dyrk kinases regulate phosphorylation of doublecortin, cytoskeletal organization, and neuronal morphology. Cytoskeleton (Hoboken). 2012 Feb 22. doi: 10.1002/cm.21021. [Epub ahead of print] PMID: 22359282
Lerch JK, Kuo F, Motti D, Morris R, Bixby JL, Lemmon VP. Isoform diversity and regulation in peripheral and central neurons revealed through RNA-Seq. PLoS One. 2012;7(1):e30417. Epub 2012 Jan 17. PMID: 22272348
Hutson TH, Buchser WJ, Bixby JL, Lemmon VP, Moon LD. Optimization of a 96-Well Electroporation Assay for Postnatal Rat CNS Neurons Suitable for Cost-Effective Medium-Throughput Screening of Genes that Promote Neurite Outgrowth. Front Mol Neurosci. 2011;4:55. Epub 2011 Dec 23. PMID: 22207835
Lerch JK, Bixby JL, Lemmon VP. Isoform diversity and its importance for axon regeneration. Neuropathology. 2011 Dec 13. doi: 10.1111/j.1440-1789.2011.01280.x. [Epub ahead of print] PMID: 22151581
Daftarian P, Chowdhury R, Ames P, Wei C, King AD, de Rivero Vaccari JP, Dillon L, Price J, Leung H, Ashlock B, Mesri E, Perez V, Züchner S, Reiser J, Lemmon V, Keane RW. In vivo electroporation and non-protein based screening assays to identify antibodies against native protein conformations. Hybridoma (Larchmt). 2011 Oct;30(5):409-18. PMID: 22008067
Daftarian P, Kaifer AE, Li W, Blomberg BB, Frasca D, Roth F, Chowdhury R, Berg EA, Fishman JB, Al Sayegh HA, Blackwelder P, Inverardi L, Perez VL, Lemmon V, Serafini P. Peptide-conjugated PAMAM dendrimer as a universal DNA vaccine platform to target antigen-presenting cells. Cancer Res. 2011 Dec 15;71(24):7452-62. Epub 2011 Oct 10. PMID: 21987727
Visser U, Abeyruwan S, Vempati U, Smith RP, Lemmon V, Schurer SC. BioAssay Ontology (BAO): A Semantic Description of Bioassays and High-Throughput Screening Results. BMC Bioinformatics. 2011 Jun 24;12(1):257. [Epub ahead of print]
Lemmon VP, Jia Y, Shi Y, Holbrook SD, Bixby JL, Buchser W., Challenges in Small Screening Laboratories: Implementing an On-Demand Laboratory Information Management System. Comb Chem High Throughput Screen. 2011 Jun 1. [Epub ahead of print]
Schürer SC, Vempati U, Smith R, Southern M, Lemmon V. BioAssay ontology annotations facilitate cross-analysis of diverse high-throughput screening data sets. J Biomol Screen. 2011 Apr;16(4):415-26. PMID:21471461
Hellal F, Hurtado A, Ruschel J, Flynn KC, Laskowski CJ, Umlauf M, Kapitein LC, Strikis D, Lemmon V, Bixby J, Hoogenraad CC, Bradke F. Microtubule stabilization reduces scarring and causes axon regeneration after spinal cord injury. Science. 2011 Feb 18;331(6019):928-31. PMID: 21273450 9:e86186. doi: 10.1371/journal.pone.0086186. PMID: 24489698
Smith RP, Lerch-Haner JK, Pardinas JR, Buchser WJ, Bixby JL, Lemmon VP. Transcriptional profiling of intrinsic PNS factors in the postnatal mouse. Mol Cell Neurosci. 2011 Jan;46(1):32-44. Epub 2010 Aug 7. PMID: 20696251 This work was inspired by Stephen Davies and Jerry Silvers seminal paper on CNS microtransplantation. Nature. 1997 390:680
Buchser WJ, Slepak TI, Gutierrez-Arenas O, Bixby JL, Lemmon VP. Kinase/phosphatase overexpression reveals pathways regulating hippocampal neuron morphology. Mol Syst Biol. 2010 Jul 27;6:391.PMID: 20664637 The noise reduction method used in this paper was inspired by Lucas Pelkmans' amazing talk at the Keystone Omics meets Cell Biology meeting in 2009.
Gavert N, Ben-Shmuel A, Lemmon V, Brabletz T, Ben-Ze'ev A. Nuclear factor-kappaB signaling and ezrin are essential for L1-mediated metastasis of colon cancer cells. J Cell Sci. 2010 Jun 15;123(Pt 12):2135-43. Epub 2010 May 25.PMID: 20501702.
Usher LC, Johnstone A, Ertürk A, Hu Y, Strikis D, Wanner IB, Moorman S, Lee JW, Min J, Ha HH, Duan Y, Hoffman S, Goldberg JL, Bradke F, Chang YT, Lemmon VP, Bixby JL. J Neurosci. 2010 Mar 31;30(13):4693-706.PMID: 20357120.
Murray G. Blackmore, Darcie L. Moore, Robin P. Smith, Jeffrey L. Goldberg, John L. Bixby, Vance P. Lemmon. High content screening of cortical neurons identifies novel regulators of axon growth. Molecular and Cellular Neuroscience. 2010 May;44(1):43-54. Epub 2010 Feb 14. PMID: 20159039
Nakamura Y, Lee S, Haddox CL, Weaver EJ, Lemmon VP. Role of the cytoplasmic domain of the L1 cell adhesion molecule in brain development. J Comp Neurol.. 2010 Apr 1;518(7):1113-32.PMID: 20127821
Moore D, Blackmore M, Hu Y, Klaus H Kaestner, Bixby JL, Lemmon VP, Goldberg J. KLF Family Members Regulate Intrinsic Axon Regeneration Ability. Science. 2009 Oct 9.
Tapanes-Castillo A, Weaver EJ, Smith RP, Kamei Y, Caspary T, Hamilton-Nelson KL, Slifer SH, Martin ER, Bixby JL, Lemmon VP. A modifier locus on chromosome 5 contributes to L1 cell adhesion molecule X-linked hydrocephalus in mice. Neurogenetics. 2009 Jun 30.
Yeaney NK, He M, Tang N, Malouf AT, O'Riordan MA, Lemmon V, Bearer CF. Ethanol inhibits L1 cell adhesion molecule tyrosine phosphorylation and dephosphorylation and activation of pp60(src). J Neurochem. 2009 May 4.
Wanner IB, Deik A, Torres M, Rosendahl A, Neary JT, Lemmon VP, Bixby JL. A new in vitro model of the glial scar inhibits axon growth. Glia. 2008 Nov 15;56(15):1691-709.
Bechara A, Nawabi H, Moret F, Yaron A, Weaver E, Bozon M, Abouzid K, Guan JL, Tessier-Lavigne M, Lemmon V, Castellani V. FAK-MAPK-dependent adhesion disassembly downstream of L1 contributes to semaphorin3A-induced collapse. EMBO J. 2008 Jun 4;27(11):1549-62. Epub 2008 May 8.
Smith RP, Buchser WJ, Lemmon MB, Pardinas JR, Bixby JL, Lemmon VP. EST Express: PHP/MySQL based automated annotation of ESTs from expression libraries. BMC Bioinformatics. 2008 Apr 10;9:186.
Tyukhtenko S, Deshmukh L, Kumar V, Lary J, Cole J, Lemmon V, Vinogradova O. Characterization of the neuron-specific L1-CAM cytoplasmic tail: naturally disordered in solution it exercises different binding modes for different adaptor proteins. Biochemistry. 2008 Apr 1;47(13):4160-8. Epub 2008 Mar 6..
Buchser WB, Pardinas JR, Shi Y, Bixby JL, Lemmon VP. 96-Well electroporation method for transfection of mammalian central neurons. Biotechniques. 2006 Nov; 41:619-224.
Tang N, He M, O'Riordan MA, Farkas C, Buck K, Lemmon V, Bearer CF. Ethanol inhibits L1 cell adhesion molecule activation of mitogen-activated protein kinases. J Neurochem. 2006 Mar;96(5):1480-90.
Liu J, Ball SL, Yang Y, Mei P, Zhang L, Shi H, Kaminski HJ, Lemmon VP, Hu H. A genetic model for muscle-eye-brain disease in mice lacking protein O-mannose 1,2-N-acetylglucosaminyltransferase (POMGnT1). Mech Dev. 2006 Feb 1
Itoh K, Fushiki S, Kamiguchi H, Arnold B, Altevogt P, Lemmon V. Disrupted Schwann cell-axon interactions in peripheral nerves of mice with altered L1-integrin interactions. Mol Cell Neurosci. 2005 Dec;30(4):624-9.
Cheng L, Lemmon S, Lemmon V. RanBPM is an L1-interacting protein that regulates L1-mediated mitogen-activated protein kinase activation. J Neurochem. 2005 Aug;94(4):1102-10. Epub 2005 Jul 5.
Newpher TM, Smith RP, Lemmon V, Lemmon SK. In vivo dynamics of clathrin and its adaptor-dependent recruitment to the actin-based endocytic machinery in yeast. Dev Cell. 2005 Jul;9(1):87-98.
Itoh K, Shimono K, Lemmon V. Dephosphorylation and internalization of cell adhesion molecule L1 induced by theta burst stimulation in rat hippocampus. Mol Cell Neurosci. 2005 Jun;29(2):245-9.
Cheng L, Itoh K, Lemmon V. L1-mediated branching is regulated by two ezrin-radixin-moesin (ERM)-binding sites, the RSLE region and a novel juxtamembrane ERM-binding region. J Neurosci. 2005 Jan 12;25(2):395-403.
Cheng L and Lemmon V. Pathological missense mutations of neural cell adhesion molecule L1 affect neurite outgrowth and branching on an L1 substrate. Mol Cell Neurosci. (2004) 27:522-530. Download Paper PDF Download Supplementary Data PDF
Itoh, K, Cheng L, Kamei Y, Fushiki S, Kamiguchi H, Gutwein P, Stoeck A, Arnold B, Altevogt P, and Lemmon V. Brain development in mice lacking L1-L1 homophilic adhesion. J Cell Biol. (2004)165:145-154
Review Articles
Isoform diversity and its importance for axon regeneration. Lerch JK, Bixby JL, Lemmon VP. Neuropathology. 2011 Dec 13. doi: 10.1111/j.1440-1789.2011.01280.
Kooy RF, Verhoye MV, Lemmon V, Van Der Linden A. Brain studies of mouse models for neurogenetic disorders using in vivo magnetic resonance imaging (MRI). European Journal of Human Genetics. 2001; 9:153-159.
Brümmendorf, T., and Lemmon, V. IgCAMs: Cis-interactions and cytoplasmic adaptors regulate adhesion. Current Opinion in Cell Biology, 13:611-618, 2001
Kamiguchi, H., and Lemmon, V. IgCAMs: Bi-directional signals underlying neurite growth. Current Opinion in Cell Biology, 12:598-605, 2000
Long, K.E. and Lemmon, V. Dynamic regulation of cell adhesion molecules during axon outgrowth. J. Neurobiol. 44:230-245, 2000
Kamiguchi, H., Hlavin, M.L., Yamasaki, M., Lemmon, V. Adhesion molecules and inherited diseases of the nervous system. Annual Reviews of Neuroscience, 1998, 21:97-125
Kamiguchi, H., Hlavin, M.L., Lemmon, V. Role of L1 in neural development: what the knockouts tell us. Mol. Cell Neurosci. 12:48-55, 1998.
2000-2002
A.W. Schaefer, Y. Kamei, H. Kamiguchi, E.V. Wong, I. Rapoport, T. Kirchhausen, C.M. Beach, G. Landreth, S.K. Lemmon, V. Lemmon. L1 endocytosis is controlled by a phosphorylation-dephosphorylation cycle stimulated by outside-in signaling by L1. J. Cell Biology, 157: 1223–1232, 2002.
Brümmendorf, T., and Lemmon, V. IgCAMs: Cis-interactions and cytoplasmic adaptors regulate adhesion. Current Opinion in Cell Biology, 13:611-618, 2001.
Long, K.E., Asou, H., Snider, M.D., Lemmon, V., The role of endocytosis in regulating L1 mediate adhesion. J. Biol. Chem., 276: 1285-1290, 2001.
De Angelis, E., Brümmendorf, T., Cheng, L., Lemmon, V., and Kenwrick, S. Alternative Use of a Mini Exon of the L1 Gene Affects L1 Binding to Neural Ligands, J. Biol. Chem., 276 :32738-32742, 2001, J. Biol. Chem., 276 :32738-32742.
Kooy, R.F., Verhoye, M., Lemmon, V. and Van Der Linden, A., Analysis of mouse brain by magnetic resonance imaging (MRI), Eur J. Hum Genet. 9:153-159, 2001
Kamiguchi, H., Lemmon, V. Recycling of the Cell Adhesion Molecule L1 in Axonal Growth Cones J. Neurosci., 15:3676-3686, 2000.
Esch, T., Lemmon, V., Banker, G. Differential effects of NgCAM and N-cadherin on the development of axons and dendrites by cultured hippocampal neurons. J. Neurocytology 29:215-223, 2000
Long, K.E. and Lemmon, V. Dynamic regulation of cell adhesion molecules during axon outgrowth. J. Neurobiol. 44:230-245, 2000.
Kamiguchi, H., and Lemmon, V. IgCAMs: Bi-directional signals underlying neurite growth. Current Opinion in Cell Biology, 12:598-605, 2000.
1998-1999
Kamiguchi, K., Schaefer, A.S., Long, K.E., Yamasaki, M., and Lemmon, V., The function of the cytoplasmic domain of the cell adhesion molecule L1 in normal and abnormal brain development. Frontiers of Neural Development, Keio Symposium, Vol 2, 241-248, 1999
Kamiguchi, K., and Lemmon, V. Signal-mediated sorting of the cell adhesion molecule L1: role of its cytoplasmic domain. Frontiers of Neural Development, Keio Symposium, Vol 2, 255-260, 1999
Yamasaki, M., and Lemmon, V., Mutations in L1CAM correlate with severity of developmental defects in brain development, Frontiers of Neural Development, Keio Symposium Vol 2, 273-275, 1999
Williams, S., Leventhal, C., Lemmon, V., Nedergaard, M., Goldman, S.A. Estrogen promotes the initial migration and inception of NgCAM-dependent calcium-signaling by new neurons of the adult songbird brain. Mol. Cell Neurosci. 13:41-55, 1999
Esch, T., Lemmon, V., Banker, G. Local presentation of substrate molecules directs axon specification by cultured hippocampal neurons. J. Neurosci. 19:6417-6326, 1999
Haney, C.A., Sahenk, Z., Li, C., Lemmon, V.P., Roder, J., Trapp, B.D. Heterophilic binding of L1 on unmyelinated sensory axons mediates Schwann cell adhesion and is required for axonal survival. J. Cell Biol. 146:1173-1183, 1999
Schaefer, A.W., Kamiguchi, H., Wong, E.V., Beach, C.M., Landreth, G., and Lemmon, V. Activation of the MAPK Signal Cascade by the Neural Cell Adhesion Molecule L1 Requires L1 Internalization. J. Biol. Chem. 274:37965-37973., 1999
Nayeem, N., Steve Silletti, S., Xiu-Ming Yang, X.-M., Vance A. Lemmon, V.P., Reisfeld, R.A., Stallcup, W.B., Montgomery, A.M.P. A potential role for the plasmin(ogen) system in the posttranslational cleavage of the neural cell adhesion molecule L1'. J. Cell Science 112:4739-4749, 1999
Kamiguchi, H., Hlavin, M.L., Yamasaki, M., Lemmon, V. Adhesion molecules and inherited diseases of the nervous system. Annual Reviews of Neuroscience, 1998, 21:97-125.
Fransen E, D'Hooge R, Van Camp G, Verhoye M, Sijbers J, Reyniers E, Soriano P, Kamiguchi H, Willemsen R, Koekkoek SKE, Zeeuw CI, Deyn PPD, Van der Linden A, Lemmon V, Kooy RF, Willems PJ. L1 knockout mice show dilated ventricles, vermis hypoplasia and impaired exploration patterns. Human Molecular Genetics. 1998;7(6):999-1009.
Kamiguchi, H., Lemmon, V. A neuronal form of the cell adhesion molecule L1 contains a tyrosine-based signal required for sorting to the axonal growth cone. J. Neurosci., 18:3749-3756, 1998
Kamiguchi, H., Long, K.E., Pendergast, M., Schaefer, A.W., Rapoport, I, Kirchhausen, T., Lemmon, V. The Neural Cell Adhesion Molecule L1 Interacts with the AP-2 Adaptor and Is Endocytosed via the Clathrin-Mediated Pathway. J. Neurosci. 1998 18:5311-5321
Schaefer, A.. and Lemmon, V. Signal transduction, neurite growth and IG superfamily adhesion molecules in the vertebrate nervous system. Ig superfamily molecules in the nervous system, Ed. P. Sonderegger, Harwood Academic Pub. 1998
1996-1997
Drazba, J., Liljelund, P., Smith, C., Payne, R., Lemmon, V. Growth cone interactions with purified cell and substrate adhesion molecules visualized by interference reflection microscopy. Dev. Brain Res., 100:183-197, 1997
Yamasaki M, Thompson P, Lemmon V. CRASH Syndrome: Mutations in L1CAM Correlate with Severity of the Disease. Neuropediatrics. 1997; 28:175-178.
Kamiguchi, H., Lemmon, V., The neural cell adhesion molecule L1: signaling pathways and growth cone motility. J. Neurosci. Res., 49:1-8, 1997
Burden-Gulley, S.M., Pendergast, M. Lemmon, V., The role of the cell adhesion molecule L1 in axonal extension, growth cone motility and signal transduction, Cell and Tissue Res. 290:415-422, 1997
Goldman, S.A., Williams, S., Barami, K., Lemmon, V., Nedergaard, M. Transient coupling of Ng-CAM expression to Ng-CAM-dependent calcium-signalling during migration of new neurons in the adult songbird forebrain. Mol. and Cell Neurosci. 7: 29-45, 1996
Wong, E.V., Schaefer, A.W., Landreth, G., Lemmon, V. Casein kinase II phosphorylates the neural cell adhesion molecule L1, J. Neurochem., 66:779-786, 1996
Montgomery, A., Becker, J.C., Siu, C.-H., Lemmon, V.P., Cheresh, D.A., Pancock, J.D., Zhao, X., Reisfeld, R.A. Human neural cell adhesion molecule L1 and rat homologue NILE are ligands for integrin alphaVbeta3, J. Cell Biol. 132:475-485, 1996
Burden-Gulley, S.M., Lemmon, V. L1/8D9, N-cadherin and laminin induce distinct distribution patterns of cytoskeletal elements in growth cones. Cell Motility and the Cytoskeleton 35:1-23, 1996
Payne, H.R., Hemperly, J.J., Lemmon, V. N-cadherin expression and function in cultured oligodendrocytes. Dev. Br. Res. 97:9-15, 1996
Wong, E.V., Schaefer, A.W., Landreth, G. and Lemmon, V. Involvement of p90rsk in neurite outgrowth mediated by the cell adhesion molecule L1. J. Biol. Chem. 271:18217-18233, 1996
1990-1995
Ring, C., Lemmon, V., Halfter, W. Two chondroitin sulfate proteoglycans differentially expressed in the developing chick visual system. Dev. Biol. 168:11-27, 1995
Burden-Gulley, S.M., Payne, H.R., Lemmon, V. Growth cones are actively influenced by substrate-bound adhesion molecules. J. Neurosci., 15:4370-4381, 1995
Wong, E.V., Kenwrick, S, Willems, and V. Lemmon. Mutations in the cell adhesion molecule L1 cause mental retardation. Trends in Neuroscience. 18:168-172
Brittis, P.A., Lemmon, V., Rutishauser, U., Silver, J. Cell adhesion molecules in concert with repulsive molecules govern intraretinal axon guidance: a time lapse study of the living retina. Mol and Cell Neurobiology, 6:433-449, 1995
Fransen, E., Lemmon, V., Van Camp, G., Vits, L., Coucke, P., Willems, P.J. CRASH syndrome: a clinical spectrum of corpus callosum hypoplasia, retardation, adducted thumbs, spastic paraparesis and hydrocephalus due to mutations in one single gene, L1. European Journal of Human Genetics. 3:273-284, 1995
Willbold, E., Reinicke, M., Lance-Jones, C., Lagenaur, C., Lemmon, V., Layer, P.G. Muller glia stabilizes cell columns during retinal development: lateral cell migration but not neuropil growth is inhibited in mixed chick-quail retinospheroids. Eur. J. Neurosci. 7:2277-2284, 1995
Wong EV, Cheng G, Payne HR, Lemmon V. The cytoplasmic domain of the cell adhesion molecule L1 is not required for homophilic adhesion. Neuroscience Letters. 1995; 200:155-158.
Lemmon, V. "How to Talk to Children" in : How-To Book; a primer on working with schools, Soc. for Neuroscience, Committee on Neuroscience Literacy, 1992-1995, editor 1994 and 1995
Seminars in Developmental Biology: 6:2 Cell Interaction Molecules in Development, Guest Editors: U. Rutishauser and V. Lemmon 1995
Barami, K., Kirschenbaum, B., Lemmon, V., Goldman, S. N-cadherin and NgCAM/8D9 are involved serially in the migration of newly generated neurons into the adult song bird brain. Neuron, 13:567-582, 1994
Sloan, S.F., Lemmon, V. and Koenig, E. Monoclonal antibody 8A2 induced retraction is mediated by protein phosphorylation in goldfish retinal ganglion cell axons. Dev. Biol., 156:230-242, 1993
Goldman, S.A., Lemmon, V., and Chin, S.S.-M. Migration of newly generated neurons upon ependymally-derived radial guide cells in explant cultures of the adult avian forebrain. Glia, 8:150-160, 1993
Payne, H.R., and Lemmon V. Glial cells of the O-2A lineage bind preferentially to N-cadherin and develop distinct morphologies. Dev. Biol. 159:595-607, 1993
Barry, C.P., Xie, J., Lemmon, V., and Young, A.P. Molecular characterization of a multipromoter gene encoding a chicken filamin protein. J. Biological Chemistry 268:25577-25586, 1993
Lemmon, V., Burden, S.M., Payne, H.R., Elmslie, G.J. and Hlavin, M.L. Neurite growth on different substrates: permissive versus instructive influences and the role of adhesive strength. J. Neuroscience, 12:818-826, 1992 My only experiment to make it into a text book. :-)
Payne, H.R., Burden, S. and Lemmon, V. Modulation of growth cone morphology by substrate bound cell adhesion molecules. Cell Motility and the Cytoskeleton, 21:65-73, 1992
Sloan, S.F., Lemmon, V. and Koenig, E. Characterization of the retraction response of goldfish axons triggered by monoclonal antibody 8A2 in vitro. Cell Motility and the Cytoskeleton, 23:279-301, 1992
Drazba, J., Pierce, M., and Lemmon, V. Studies of the developing chick retina using monoclonal antibody 8A2 that recognizes a novel set of gangliosides. Dev. Biol. 145: 154-163, 1991
Hlavin, M.L. and Lemmon, V. Molecular structure and functional testing of human L1: an interspecies comparison. Genomics, 11, 416-423, 1991 First publication of human L1CAM sequence.
Letourneau, P.C., Roche, F.K., Shattuck, T.A., Lemmon, V., and Takeichi, M. Interactions of Schwann cells with neurites and with other Schwann cells involve the calcium-dependent adhesion molecule, N-cadherin. J. Neurobiology, 22:707-720, 1991.
Cervello, M., Lemmon, V., Landreth, G., and Rutishauser, U. Phosphorylation-dependent regulation of neurite fasciculation. Proc. Natl. Acad. Sci., USA, 88:10548-10552, 1991
Letourneau, P.C., Shattuck, T.A., Roche, F., Takeichi, M., and Lemmon, V., Nerve growth cone migration onto Schwann cells involves the calcium-dependent adhesion molecule, N-cadherin. Dev. Bio. 138:430-442, 1990
Drazba, J. and Lemmon, V., The role of cell adhesion molecules in neurite outgrowth on Muller cells. Dev. Bio. 138:82-93, 1990
Snow, D.M., Lemmon, V., Carrino, D.A., Caplan, A.I., and Silver, J. Sulfated proteoglycans present in astroglial barriers during development in vivo inhibit neurite outgrowth in vitro. Exp. Neurol. 109:111-130, 1990
1977-1989
Lemmon, V., Farr, K., Lagenaur, C. L1 mediated axon outgrowth occurs via a homophilic binding mechanism. Neuron, 2:1597-1603, 1989 Cool assay to demonstrate homophilic binding in neurite growth.
Lemmon, S.K., Lemmon, V.P., and Jones, E.W. Characterization of yeast clathrin and anti-clathrin heavy chain monoclonal antibodies. J. Cellular Biochem. 36: 329-340, 1988
Lemmon, V., Farr, K. and Lagenaur, C. The role of a cell adhesion molecule in neurite outgrowth and regeneration. In: Cell Interactions in Visual Development. S.R. Hilger and J.B. Sheffield (Eds.), Springer Verlag, 1988
Lemmon, V. A monoclonal antibody that binds to the surface of photoreceptors. Dev. Brain Res. 39:117-123, 1988.
Risau, W. and Lemmon, V. Changes in the vascular extracellular matrix during embryonic vasculogenesis and angiogenesis. Dev. Bio. 125:441-450, 1988
Hyndman, A.G. and Lemmon, V. Neurons and glia in purified retinal cultures identified by monoclonal antibodies to intermediate filaments. Neurosci. Lett. 75:121-126, 1987
Lagenaur, C. and Lemmon, V. A L1-like molecule, the 8D9 antigen, is a potent substrate for neurite extension. Proc. Natl. Acad. Sci., USA 84:7753-7757, 1987 First purified CAM to promote axon growth. Introduction of the use of dissolved nitrocellulose to create substrates for cell culture.
Lemmon, V. The localization of a filamin-like protein in glia of the chick central nervous system. J. Neurosci. 6:43-51, 1986
Lemmon, V. A monoclonal antibody that binds to cones. Invest. Ophthalmol. and Vis. Sci. 27:831-836, 1986
Lemmon, V. and McLoon, S. The appearance of an L1 like molecule in the chick primary visual pathway. J. Neurosci. 6:2987-2994, 1986
Lemmon, V. Monoclonal antibodies specific for glia in the chick central nervous system. Dev. Brain Res. 23:111-120, 1985
Lemmon, V. and Rieser, G. The development distribution of vimentin in the chick retina. Dev. Brain Res. 11:191-198, 1983.
Post-Doc
Lemmon, V., Staros, E.B., Perry, H.E., and Gottlieb, D.I. A monoclonal antibody which binds to the surface of chick brain cells and myotubes: Cell selectivity and properties of the antigen. Dev. Brain Res. 255:349-360, 1982.
Lemmon, V. and Gottlieb, D.I. Monoclonal antibodies selective for the inner portion of the chick retina. J. Neurosci. 2:531-535, 1982
Simmons, P.A., Lemmon, V., and Pearlman, A.L. Afferent and efferent connections of the striate and extrastriate visual cortex of the normal and reeler mouse. .J. Comp. Neurol. 211:295-308, 1982
Lemmon, V. and Gottlieb, D.I. Techniques for the production of monoclonal antibodies against the chick retina. In: Syllabus of the 1981 short course of the Society for Neuroscience: New Approaches in Developmental Neurobiology.
Lemmon, V. and Pearlman, A.L. Does laminar position determine the receptive field properties of cortical neurons: A study of corticotectal cells in area 17 of the normal mouse and reeler mouse. J. Neurosci. 1:83-93, 1981
Grad School
Anderson, K.V. and Lemmon, V. The effects of constant light on visually guided behavior. In: The Effects of Constant Light on Visual Processes. T.P. Williams and B.N. Baker (Eds.), Plenum Press, 1980.
Anderson, K.V., Lemmon, V., and O'Steen, W.K. Neurophysiological properties of visual neurons in rats with light damaged retina. In: The Effects of Constant Light on Visual Processes. T.P. Williams and B.N. Baker (Eds.), Plenum Press, 1980.
Lemmon, V. and Anderson, K.V. Behavioral correlates of constant light-induced retinal degeneration. Exp. Neurol. 63:34-49, 1979.
Lemmon, V. and Anderson, K.V. Central neurophysiologic correlates of constant light-induced retinal degeneration. Exp. Neurol. 63:50-75, 1979.
Anderson, K.V., Lemmon, V., and Rosing, H.S. Response properties of cells in the dorsal lateral geniculate nucleus of the albino rat. J. Neurosci. Res. 3:143-152, 1977.
Validation study of neurotrophin-3-releasing chitosan facilitation of neural tissue generation in the severely injured adult rat spinal cord. Oudega M, Hao P, Shang J, Haggerty AE, Wang Z, Sun J, Liebl DJ, Shi Y, Cheng L, Duan H, Sun YE, Li X, Lemmon VP. Exp Neurol. 2019 Feb;312:51-62. doi: 10.1016/j.expneurol.2018.11.003. Epub 2018 Nov 22. PMID: 30471251. THIS PROJECT WAS FASCINATING AND A LOT OF WORK. HOPEFULLY IT IS USEFUL. PLEASE SEE THE COMMENTARY BY SCHAFFRAN AND BRADKE.
The effect of Jun dimerization on neurite outgrowth and motif binding. Danzi MC, Mehta ST, Dulla K, Zunino G, Cooper DJ, Bixby JL, Lemmon VP. Mol Cell Neurosci. 2018 Oct;92:114-127. doi: 10.1016/j.mcn.2018.08.001. Epub 2018 Aug 3. PMID: 30077771
Scaffold Ranking and Positional Scanning Identify Novel Neurite Outgrowth Promoters with Nanomolar Potency. Al-Ali H, Debevec G, Santos RG, Houghten RA, Davis JC, Nefzi A, Lemmon VP, Bixby JL, Giulianotti MA. ACS Med Chem Lett. 2018 Sep 24;9(10):1057-1062. doi: 10.1021/acsmedchemlett.8b00425. eCollection 2018 Oct 11. PMID: 30344917
THIS PAPER IS CRAZY! WE SCREENED OVER 400 MILLION COMPOUNDS ON PRIMARY NEURONS! WE DISCOVERED SOME VERY POTENT NEURITE GROWTH PROMOTERS.
Injury type-dependent differentiation of NG2 glia into heterogeneous astrocytes. Amber R. Hackett, Stephanie L. Yahn, Kirill Lyapichev, Angela Dajnoki, Do-Hun Lee, Mario Rodriguez, Natasha Cammer, Ji Pak, Saloni T. Mehta, Olaf Bodamer, Vance P. Lemmon, Jae K. Lee https://doi.org/10.1016/j.expneurol.2018.07.001
The Assay Guidance Manual: Quantitative Biology and Pharmacology in Preclinical Drug Discovery. Coussens NP, Sittampalam GS, Guha R, Brimacombe K, Grossman A, Chung TDY, Weidner JR, Riss T, Trask OJ, Auld D, Dahlin JL, Devanaryan V, Foley TL, McGee J, Kahl SD, Kales SC, Arkin M, Baell J, Bejcek B, Gal-Edd N, Glicksman M, Haas JV, Iversen PW, Hoeppner M, Lathrop S, Sayers E, Liu H, Trawick B, McVey J, Lemmon VP, Li Z, McManus O, Minor L, Napper A, Wildey MJ, Pacifici R, Chin WW, Xia M, Xu X, Lal-Nag M, Hall MD, Michael S, Inglese J, Simeonov A, Austin CP. Clin Transl Sci. 2018 Jun 7. doi: 10.1111/cts.12570. PMID: 29877628
Can chromatin accessibility be exploited for axon regeneration? Danzi MC, O'Neill N, Bixby JL, Lemmon VP. Dev Neurobiol. 2018 Apr 17. doi: 10.1002/dneu.22598. Review. PMID: 29664188
Reactive oxygen species regulate axonal regeneration through the release of exosomal NADPH oxidase 2 complexes into injured axons. Hervera A, De Virgiliis F, Palmisano I, Zhou L, Tantardini E, Kong G, Hutson T, Danzi MC, Perry RB, Santos CXC, Kapustin AN, Fleck RA, Del Río JA, Carroll T, Lemmon V, Bixby JL, Shah AM, Fainzilber M, Di Giovanni S. Nat Cell Biol. 2018 Mar;20(3):307-319. doi: 10.1038/s41556-018-0039-x. Epub 2018 Feb 12. Erratum in: Nat Cell Biol. 2018 Mar 8; PMID: 29434374
Region specific knock-out reveals distinct roles of chromatin modifiers in adult neurogenic niches. Rhodes CT, Zunino G, Huang SA, Cardona SM, Cardona AE, Berger MS, Lemmon VP, Lin CA. Cell Cycle. 2018;17(3):377-389. doi: 10.1080/15384101.2018.1426417. PMID: 29433384
High Content Screening of Mammalian Primary Cortical Neurons. Motti D, Blackmore M, Bixby JL, Lemmon VP. Methods Mol Biol. 2018;1683:293-304. doi: 10.1007/978-1-4939-7357-6_17 PMID: 29082499
3D Visualization of Individual Regenerating Retinal Ganglion Cell Axons Reveals Surprisingly Complex Growth Paths. Bray ER, Noga M, Thakor K, Wang Y, Lemmon VP, Park KK, Tsoulfas P. eNeuro. 2017 Aug 29;4(4). pii: ENEURO.0093-17.2017. doi: 10.1523/ENEURO.0093-17.2017. eCollection 2017 Jul-Aug. PMID: 28856242
Stress Increases Peripheral Axon Growth and Regeneration through Glucocorticoid Receptor-Dependent Transcriptional Programs. Lerch JK, Alexander JK, Madalena KM, Motti D, Quach T, Dhamija A, Zha A, Gensel JC, Webster Marketon J, Lemmon VP, Bixby JL, Popovich PG. eNeuro. 2017 Aug 21;4(4). pii: ENEURO.0246-17.2017. doi: 10.1523/ENEURO.0246-17.2017. eCollection 2017 Jul-Aug. PMID: 28828403
Optic nerve regeneration in mammals: Regenerated or spared axons? Fischer D, Harvey AR, Pernet V, Lemmon VP, Park KK. Exp Neurol. 2017 Jul 14. pii: S0014-4886(17)30183-8. doi: 10.1016/j.expneurol.2017.07.008. Review. PMID: 28716559
Identification of miRNAs involved in DRG neurite outgrowth and their putative targets. Motti D, Lerch JK, Danzi MC, Gans JH, Kuo F, Slepak TI, Bixby JL, Lemmon VP. FEBS Lett. 2017 Jun 19. doi: 10.1002/1873-3468.12718. PMID: 28626869
The mTOR substrate S6 Kinase 1 (S6K1) is a negative regulator of axon regeneration and a potential drug target for Central Nervous System injury. Al-Ali H, Ding Y, Slepak T, Wu W, Sun Y, Martinez Y, Xu XM, Lemmon VP, Bixby JL. J Neurosci. 2017 Jun 16. pii: 0931-17. doi: 10.1523/JNEUROSCI.0931-17.2017. PMID: 28626016
Genetically modifying transcription factors to promote CNS axon regeneration. Mehta ST, Bixby JL, Lemmon VP. Neural Regen Res. 2017 May;12(5):737-738. doi: 10.4103/1673-5374.206637. No abstract available.PMID: 28616023
Phenotypic screening with primary neurons to identify drug targets for regeneration and degeneration. Cooper DJ, Zunino G, Bixby JL, Lemmon VP. Mol Cell Neurosci. 2017 Apr;80:161-169. doi: 10.1016/j.mcn.2016.07.001. Epub 2016 Jul 18. Review. PMID: 27444126
Developing a data sharing community for spinal cord injury research. Callahan A, Anderson KD, Beattie MS, Bixby JL, Ferguson AR, Fouad K, Jakeman LB, Nielson JL, Popovich PG, Schwab JM, Lemmon VP; FAIR Share Workshop Participants.
Exp Neurol. 2017 May 30. pii: S0014-4886(17)30137-1. Review. PMID: 28576567
Macrophage Transcriptional Profile Identifies Lipid Catabolic Pathways That Can Be Therapeutically Targeted after Spinal Cord Injury.
Zhu Y, Lyapichev K, Lee DH, Motti D, Ferraro NM, Zhang Y, Yahn S, Soderblom C, Zha J, Bethea JR, Spiller KL, Lemmon VP, Lee JK.
J Neurosci. 2017 Mar 37:2362-2376. PMID: 28130359
Gao H, Danzi MC, Choi CS, Taherian M, Dalby-Hansen C, Ellman DG, Madsen PM, Bixby JL, Lemmon VP, Lambertsen KL, Brambilla R. Opposing Functions of Microglial and Macrophagic TNFR2 in the Pathogenesis of Experimental Autoimmune Encephalomyelitis. Cell Rep. 2017 Jan 3;18(1):198-212. PMID: 2805224
Mehta ST, Luo X, Park KK, Bixby JL, Lemmon VP. Hyperactivated Stat3 boosts axon regeneration in the CNS. Exp Neurol. 2016 Apr 6. pii: S0014-4886(16)30049-8. PMID: 27060489
Callahan A, Abeyruwan SW, Al-Ali H, Sakurai K, Ferguson AR, Popovich PG, Shah NH, Visser U, Bixby JL, Lemmon VP. RegenBase: a knowledge base of spinal cord injury biology for translational research. Database (Oxford). 2016 Apr 7;2016. pii: baw040. Print 2016. PMID: 27055827
Luo X, Ribeiro M, Bray ER, Lee DH, Yungher BJ, Mehta ST, Thakor KA, Diaz F, Lee JK, Moraes CT, Bixby JL, Lemmon VP, Park KK. Enhanced Transcriptional Activity and Mitochondrial Localization of STAT3 Co-induce Axon Regrowth in the Adult Central Nervous System. Cell Rep. 2016 Mar 29. pii: S2211-1247(16)30285-6. doi: 10.1016/j.celrep.2016.03.029. [Epub ahead of print] PMID: 27050520
Danzi MC, Motti D, Avison DL, Bixby JL, Lemmon VP. Treatment with analgesics after mouse sciatic nerve injury does not alter expression of wound healing-associated genes. Neural Regen Res. 2016 Jan;11(1):144-9. doi: 10.4103/1673-5374.169637. PMID: 26981104
Peschansky VJ, Pastori C, Zeier Z, Motti D, Wentzel K, Velmeshev D, Magistri M, Bixby JL, Lemmon VP, Silva JP, Wahlestedt C. Changes in expression of the long non-coding RNA FMR4 associate with altered gene expression during differentiation of human neural precursor cells. Front Genet. 2015 Aug 10;6:263. doi: 10.3389/fgene.2015.00263.PMID: 26322075
Beckerman SR, Jimenez JE, Shi Y, Al-Ali H, Bixby JL, Lemmon VP. Phenotypic Assays to Identify Agents That Induce Reactive Gliosis: A Counter-Screen to Prioritize Compounds for Preclinical Animal Studies. Assay Drug Dev Technol. 2015 Jul 31.
Al-Ali H, Lee DH, Danzi MC, Nassif H, Gautam P, Wennerberg K, Zuercher B, Drewry DH, Lee JK, Lemmon VP, Bixby JL. Rational Polypharmacology: Systematically Identifying and Engaging Multiple Drug Targets To Promote Axon Growth. ACS Chem Biol. 2015 Jun 24. [Epub ahead of print] PMID: 26056718
C. Soderblom, D.H. Lee, A. Dawood, M. Carballosa, A.J. Santamaria, F.D. Benavides, S. Jergova1, R. Grumbles, C. Thomas, K.K. Park, J.D. Guest, V. Lemmon, J.K. Lee, P. Tsoulfas 3D imaging of axons in transparent spinal cords from rodents and non-human primates. eNeuro, Mar, 2015 DOI: 10.1523/ENEURO.0001-15.2015
Abeyruwan S, Vempati UD, Küçük-McGinty H, Visser U, Koleti A, Mir A, Sakurai K, Chung C, Bittker JA, Clemons PA, Brudz S, Siripala A, Morales AJ, Romacker M, Twomey D, Bureeva S, Lemmon V, Schürer SC. Evolving BioAssay Ontology (BAO): modularization, integration and applications. J Biomed Semantics. 2014 Jun 3;5(Suppl 1 Proceedings of the Bio-Ontologies Spec Interest G):S5. doi: 10.1186/2041-1480-5-S1-S5. eCollection 2014.
Lemmon VP, Ferguson AR, Popovich PG, Xu XM, Snow DM, Igarashi M, Beattie CE, Bixby JL; MIASCI Consortium. Minimum information about a spinal cord injury experiment: a proposed reporting standard for spinal cord injury experiments. J Neurotrauma. 2014 31:1354-61.
Abeyruwan S, Visser U, Bixby JL Facilitating transparency in spinal cord injury studies using data standards and ontologies. Neural Regeneration Research, 2014 9:6-7
Lerch, J, Martinez, Y. Bixby, JL. Lemmon VP, cJun promotes CNS axon growth. Mol Cell. Neuroscience 2014 Feb 9;59C:97-105. doi: 10.1016/j.mcn.2014.02.002. PMID: 24521823
Beurel E, Harrington LE, Buchser W, Lemmon V, Jope RS. Astrocytes Modulate the Polarization of CD4(+) T Cells to Th1 Cells. PLoS One. 2014 9:e86257. Doi 10.1371/journal.pone.0086257. . PMID: 24489707
Tonosaki M, Itoh K, Umekage M, Kishimoto T, Yaoi T, Lemmon VP, Fushiki S. L1cam Is Crucial for Cell Locomotion and Terminal Translocation of the Soma in Radial Migration during Murine Corticogenesis. PLoS One. 2014 9:e86186. doi: 10.1371/journal.pone.0086186. PMID: 24489698
Daftarian PM, Stone GW, Kovalski L, Kumar M, Vosoughi A, Urbieta M, Blackwelder P, Dikici E, Serafini P, Duffort S, Boodoo R, Rodríguez-Cortés A, Lemmon V, Deo S, Alberola J, Perez V, Daunert S, Ager AL. A targeted and adjuvanted nanocarrier lowers the effective dose of liposomal Amphotericin B and enhances adaptive immunity in murine cutaneous leishmaniasis. J Infect Dis. 2013 208:1914-22. doi: 10.1093/infdis/jit378. PMID: 23901083
Kuboyama T, Luo X, Park K, Blackmore MG, Tojima T, Tohda C, Bixby JL, Lemmon VP, Kamiguchi H. Paxillin phosphorylation counteracts proteoglycan-mediated inhibition of axon regeneration. Exp Neurol. 2013 248:157-169. doi: 10.1016/j.expneurol.2013.06.011. PMID: 23797153
Luo X, Salgueiro Y, Beckerman SR, Lemmon VP, Tsoulfas P, Park KK. Three-dimensional evaluation of retinal ganglion cell axon regeneration and pathfinding in whole mouse tissue after injury. Exp Neurol. 2013 Mar 16. [Epub ahead of print] PMID: 23510761.
Al-Ali H, Schürer SC, Lemmon VP, Bixby JL. Chemical Interrogation of the Neuronal Kinome Using a Primary Cell-Based Screening Assay. ACS Chem Biol. 2013 Mar 19. [Epub ahead of print] PMID: 23480631
Uma Vempati; Magdalena Przydzial; Saminda Abeyruwan; Kunie Sakurai; Caty Chung; Ubbo Visser; Vance Lemmon; Stephan Schürer. Formalization Annotation and Analysis of Diverse Drug and Probe Screening Assay Datasets using the BioAssay Ontology (BAO). PLoS One. 2012;7(11):e49198. doi: 10.1371/journal.pone.0049198. Epub 2012 Nov 14..
Kishimoto T, Itoh K, Umekage M, Tonosaki M, Yaoi T, Fukui K, Lemmon VP, Fushiki S. Downregulation of L1 perturbs neuronal migration and alters the expression of transcription factors in murine neocortex. J Neurosci Res. 2012 Oct 17. doi: 10.1002/jnr.23141.
Motti D, Bixby JL, Lemmon VP. MicroRNAs and Neuronal Development. Fetal Neurology. 2012 Aug 17. [Epub ahead of print]
Jo S, Kalló I, Bardóczi Z, Arrojo E Drigo R, Zeöld A, Liposits Z, Oliva A, Lemmon VP, Bixby JL, Gereben B, Bianco AC. Neuronal hypoxia induces hsp40-mediated nuclear import of type 3 deiodinase as an adaptive mechanism to reduce cellular metabolism. J Neurosci. 2012 32:8491-500. PMID: 22723689
Buchser WJ, Smith RP, Pardinas JR, Haddox CL, Hutson T, Moon L, Hoffman SR, Bixby JL, Lemmon VP. Peripheral nervous system genes expressed in central neurons induce growth on inhibitory substrates. PLoS One. 2012;7:e38101. PMID: 22701605
Dai J, Dalal JS, Thakar S, Henkemeyer M, Lemmon VP, Harunaga JS, Schlatter MC, Buhusi M, Maness PF. EphB regulates L1 phosphorylation during retinocollicular mapping. Mol Cell Neurosci. 2012 50:201-10.
Johnstone AL , Reierson GW, Smith RP, Goldberg JL, Lemmon VP, Bixby JL. A chemical genetic approach identifies piperazine antipsychotics as promoters of CNS neurite growth on inhibitory substrates Mol Cell Neurosci. 2012 Jun;50(2):125-35. doi: 10.1016/j.mcn.2012.04.008. Epub 2012 May 3.PMID: 22561309
Murray G. Blackmore, Zimei Wang, Jessica K. Lerch, Dario Motti, Yi Ping Zhang, Christopher B. Shields, Jae K. Lee, Jeffrey L. Goldberg, Vance P. Lemmon, and John L. Bixby. Kruppel-like Factor 7 engineered for transcriptional activation promotes axon regeneration in the adult corticospinal tract. Proc. Nat. Acad. Sci. 2012 109:7517-22.
Nelersa CM, Barreras H, Runko E, Ricard J, Shi Y, Glass SJ, Bixby JL, Lemmon VP, Liebl DJ. High-Content Analysis of Proapoptotic EphA4 Dependence Receptor Functions Using Small-Molecule Libraries. J Biomol Screen. 2012 Apr 6. [Epub ahead of print] PMID: 22492230
Slepak TI, Salay LD, Lemmon VP, Bixby JL. Dyrk kinases regulate phosphorylation of doublecortin, cytoskeletal organization, and neuronal morphology. Cytoskeleton (Hoboken). 2012 Feb 22. doi: 10.1002/cm.21021. [Epub ahead of print] PMID: 22359282
Lerch JK, Kuo F, Motti D, Morris R, Bixby JL, Lemmon VP. Isoform diversity and regulation in peripheral and central neurons revealed through RNA-Seq. PLoS One. 2012;7(1):e30417. Epub 2012 Jan 17. PMID: 22272348
Hutson TH, Buchser WJ, Bixby JL, Lemmon VP, Moon LD. Optimization of a 96-Well Electroporation Assay for Postnatal Rat CNS Neurons Suitable for Cost-Effective Medium-Throughput Screening of Genes that Promote Neurite Outgrowth. Front Mol Neurosci. 2011;4:55. Epub 2011 Dec 23. PMID: 22207835
Lerch JK, Bixby JL, Lemmon VP. Isoform diversity and its importance for axon regeneration. Neuropathology. 2011 Dec 13. doi: 10.1111/j.1440-1789.2011.01280.x. [Epub ahead of print] PMID: 22151581
Daftarian P, Chowdhury R, Ames P, Wei C, King AD, de Rivero Vaccari JP, Dillon L, Price J, Leung H, Ashlock B, Mesri E, Perez V, Züchner S, Reiser J, Lemmon V, Keane RW. In vivo electroporation and non-protein based screening assays to identify antibodies against native protein conformations. Hybridoma (Larchmt). 2011 Oct;30(5):409-18. PMID: 22008067
Daftarian P, Kaifer AE, Li W, Blomberg BB, Frasca D, Roth F, Chowdhury R, Berg EA, Fishman JB, Al Sayegh HA, Blackwelder P, Inverardi L, Perez VL, Lemmon V, Serafini P. Peptide-conjugated PAMAM dendrimer as a universal DNA vaccine platform to target antigen-presenting cells. Cancer Res. 2011 Dec 15;71(24):7452-62. Epub 2011 Oct 10. PMID: 21987727
Visser U, Abeyruwan S, Vempati U, Smith RP, Lemmon V, Schurer SC. BioAssay Ontology (BAO): A Semantic Description of Bioassays and High-Throughput Screening Results. BMC Bioinformatics. 2011 Jun 24;12(1):257. [Epub ahead of print]
Lemmon VP, Jia Y, Shi Y, Holbrook SD, Bixby JL, Buchser W., Challenges in Small Screening Laboratories: Implementing an On-Demand Laboratory Information Management System. Comb Chem High Throughput Screen. 2011 Jun 1. [Epub ahead of print]
Schürer SC, Vempati U, Smith R, Southern M, Lemmon V. BioAssay ontology annotations facilitate cross-analysis of diverse high-throughput screening data sets. J Biomol Screen. 2011 Apr;16(4):415-26. PMID:21471461
Hellal F, Hurtado A, Ruschel J, Flynn KC, Laskowski CJ, Umlauf M, Kapitein LC, Strikis D, Lemmon V, Bixby J, Hoogenraad CC, Bradke F. Microtubule stabilization reduces scarring and causes axon regeneration after spinal cord injury. Science. 2011 Feb 18;331(6019):928-31. PMID: 21273450 9:e86186. doi: 10.1371/journal.pone.0086186. PMID: 24489698
Smith RP, Lerch-Haner JK, Pardinas JR, Buchser WJ, Bixby JL, Lemmon VP. Transcriptional profiling of intrinsic PNS factors in the postnatal mouse. Mol Cell Neurosci. 2011 Jan;46(1):32-44. Epub 2010 Aug 7. PMID: 20696251 This work was inspired by Stephen Davies and Jerry Silvers seminal paper on CNS microtransplantation. Nature. 1997 390:680
Buchser WJ, Slepak TI, Gutierrez-Arenas O, Bixby JL, Lemmon VP. Kinase/phosphatase overexpression reveals pathways regulating hippocampal neuron morphology. Mol Syst Biol. 2010 Jul 27;6:391.PMID: 20664637 The noise reduction method used in this paper was inspired by Lucas Pelkmans' amazing talk at the Keystone Omics meets Cell Biology meeting in 2009.
Gavert N, Ben-Shmuel A, Lemmon V, Brabletz T, Ben-Ze'ev A. Nuclear factor-kappaB signaling and ezrin are essential for L1-mediated metastasis of colon cancer cells. J Cell Sci. 2010 Jun 15;123(Pt 12):2135-43. Epub 2010 May 25.PMID: 20501702.
Usher LC, Johnstone A, Ertürk A, Hu Y, Strikis D, Wanner IB, Moorman S, Lee JW, Min J, Ha HH, Duan Y, Hoffman S, Goldberg JL, Bradke F, Chang YT, Lemmon VP, Bixby JL. J Neurosci. 2010 Mar 31;30(13):4693-706.PMID: 20357120.
Murray G. Blackmore, Darcie L. Moore, Robin P. Smith, Jeffrey L. Goldberg, John L. Bixby, Vance P. Lemmon. High content screening of cortical neurons identifies novel regulators of axon growth. Molecular and Cellular Neuroscience. 2010 May;44(1):43-54. Epub 2010 Feb 14. PMID: 20159039
Nakamura Y, Lee S, Haddox CL, Weaver EJ, Lemmon VP. Role of the cytoplasmic domain of the L1 cell adhesion molecule in brain development. J Comp Neurol.. 2010 Apr 1;518(7):1113-32.PMID: 20127821
Moore D, Blackmore M, Hu Y, Klaus H Kaestner, Bixby JL, Lemmon VP, Goldberg J. KLF Family Members Regulate Intrinsic Axon Regeneration Ability. Science. 2009 Oct 9.
Tapanes-Castillo A, Weaver EJ, Smith RP, Kamei Y, Caspary T, Hamilton-Nelson KL, Slifer SH, Martin ER, Bixby JL, Lemmon VP. A modifier locus on chromosome 5 contributes to L1 cell adhesion molecule X-linked hydrocephalus in mice. Neurogenetics. 2009 Jun 30.
Yeaney NK, He M, Tang N, Malouf AT, O'Riordan MA, Lemmon V, Bearer CF. Ethanol inhibits L1 cell adhesion molecule tyrosine phosphorylation and dephosphorylation and activation of pp60(src). J Neurochem. 2009 May 4.
Wanner IB, Deik A, Torres M, Rosendahl A, Neary JT, Lemmon VP, Bixby JL. A new in vitro model of the glial scar inhibits axon growth. Glia. 2008 Nov 15;56(15):1691-709.
Bechara A, Nawabi H, Moret F, Yaron A, Weaver E, Bozon M, Abouzid K, Guan JL, Tessier-Lavigne M, Lemmon V, Castellani V. FAK-MAPK-dependent adhesion disassembly downstream of L1 contributes to semaphorin3A-induced collapse. EMBO J. 2008 Jun 4;27(11):1549-62. Epub 2008 May 8.
Smith RP, Buchser WJ, Lemmon MB, Pardinas JR, Bixby JL, Lemmon VP. EST Express: PHP/MySQL based automated annotation of ESTs from expression libraries. BMC Bioinformatics. 2008 Apr 10;9:186.
Tyukhtenko S, Deshmukh L, Kumar V, Lary J, Cole J, Lemmon V, Vinogradova O. Characterization of the neuron-specific L1-CAM cytoplasmic tail: naturally disordered in solution it exercises different binding modes for different adaptor proteins. Biochemistry. 2008 Apr 1;47(13):4160-8. Epub 2008 Mar 6..
Buchser WB, Pardinas JR, Shi Y, Bixby JL, Lemmon VP. 96-Well electroporation method for transfection of mammalian central neurons. Biotechniques. 2006 Nov; 41:619-224.
Tang N, He M, O'Riordan MA, Farkas C, Buck K, Lemmon V, Bearer CF. Ethanol inhibits L1 cell adhesion molecule activation of mitogen-activated protein kinases. J Neurochem. 2006 Mar;96(5):1480-90.
Liu J, Ball SL, Yang Y, Mei P, Zhang L, Shi H, Kaminski HJ, Lemmon VP, Hu H. A genetic model for muscle-eye-brain disease in mice lacking protein O-mannose 1,2-N-acetylglucosaminyltransferase (POMGnT1). Mech Dev. 2006 Feb 1
Itoh K, Fushiki S, Kamiguchi H, Arnold B, Altevogt P, Lemmon V. Disrupted Schwann cell-axon interactions in peripheral nerves of mice with altered L1-integrin interactions. Mol Cell Neurosci. 2005 Dec;30(4):624-9.
Cheng L, Lemmon S, Lemmon V. RanBPM is an L1-interacting protein that regulates L1-mediated mitogen-activated protein kinase activation. J Neurochem. 2005 Aug;94(4):1102-10. Epub 2005 Jul 5.
Newpher TM, Smith RP, Lemmon V, Lemmon SK. In vivo dynamics of clathrin and its adaptor-dependent recruitment to the actin-based endocytic machinery in yeast. Dev Cell. 2005 Jul;9(1):87-98.
Itoh K, Shimono K, Lemmon V. Dephosphorylation and internalization of cell adhesion molecule L1 induced by theta burst stimulation in rat hippocampus. Mol Cell Neurosci. 2005 Jun;29(2):245-9.
Cheng L, Itoh K, Lemmon V. L1-mediated branching is regulated by two ezrin-radixin-moesin (ERM)-binding sites, the RSLE region and a novel juxtamembrane ERM-binding region. J Neurosci. 2005 Jan 12;25(2):395-403.
Cheng L and Lemmon V. Pathological missense mutations of neural cell adhesion molecule L1 affect neurite outgrowth and branching on an L1 substrate. Mol Cell Neurosci. (2004) 27:522-530. Download Paper PDF Download Supplementary Data PDF
Itoh, K, Cheng L, Kamei Y, Fushiki S, Kamiguchi H, Gutwein P, Stoeck A, Arnold B, Altevogt P, and Lemmon V. Brain development in mice lacking L1-L1 homophilic adhesion. J Cell Biol. (2004)165:145-154
Review Articles
Isoform diversity and its importance for axon regeneration. Lerch JK, Bixby JL, Lemmon VP. Neuropathology. 2011 Dec 13. doi: 10.1111/j.1440-1789.2011.01280.
Kooy RF, Verhoye MV, Lemmon V, Van Der Linden A. Brain studies of mouse models for neurogenetic disorders using in vivo magnetic resonance imaging (MRI). European Journal of Human Genetics. 2001; 9:153-159.
Brümmendorf, T., and Lemmon, V. IgCAMs: Cis-interactions and cytoplasmic adaptors regulate adhesion. Current Opinion in Cell Biology, 13:611-618, 2001
Kamiguchi, H., and Lemmon, V. IgCAMs: Bi-directional signals underlying neurite growth. Current Opinion in Cell Biology, 12:598-605, 2000
Long, K.E. and Lemmon, V. Dynamic regulation of cell adhesion molecules during axon outgrowth. J. Neurobiol. 44:230-245, 2000
Kamiguchi, H., Hlavin, M.L., Yamasaki, M., Lemmon, V. Adhesion molecules and inherited diseases of the nervous system. Annual Reviews of Neuroscience, 1998, 21:97-125
Kamiguchi, H., Hlavin, M.L., Lemmon, V. Role of L1 in neural development: what the knockouts tell us. Mol. Cell Neurosci. 12:48-55, 1998.
2000-2002
A.W. Schaefer, Y. Kamei, H. Kamiguchi, E.V. Wong, I. Rapoport, T. Kirchhausen, C.M. Beach, G. Landreth, S.K. Lemmon, V. Lemmon. L1 endocytosis is controlled by a phosphorylation-dephosphorylation cycle stimulated by outside-in signaling by L1. J. Cell Biology, 157: 1223–1232, 2002.
Brümmendorf, T., and Lemmon, V. IgCAMs: Cis-interactions and cytoplasmic adaptors regulate adhesion. Current Opinion in Cell Biology, 13:611-618, 2001.
Long, K.E., Asou, H., Snider, M.D., Lemmon, V., The role of endocytosis in regulating L1 mediate adhesion. J. Biol. Chem., 276: 1285-1290, 2001.
De Angelis, E., Brümmendorf, T., Cheng, L., Lemmon, V., and Kenwrick, S. Alternative Use of a Mini Exon of the L1 Gene Affects L1 Binding to Neural Ligands, J. Biol. Chem., 276 :32738-32742, 2001, J. Biol. Chem., 276 :32738-32742.
Kooy, R.F., Verhoye, M., Lemmon, V. and Van Der Linden, A., Analysis of mouse brain by magnetic resonance imaging (MRI), Eur J. Hum Genet. 9:153-159, 2001
Kamiguchi, H., Lemmon, V. Recycling of the Cell Adhesion Molecule L1 in Axonal Growth Cones J. Neurosci., 15:3676-3686, 2000.
Esch, T., Lemmon, V., Banker, G. Differential effects of NgCAM and N-cadherin on the development of axons and dendrites by cultured hippocampal neurons. J. Neurocytology 29:215-223, 2000
Long, K.E. and Lemmon, V. Dynamic regulation of cell adhesion molecules during axon outgrowth. J. Neurobiol. 44:230-245, 2000.
Kamiguchi, H., and Lemmon, V. IgCAMs: Bi-directional signals underlying neurite growth. Current Opinion in Cell Biology, 12:598-605, 2000.
1998-1999
Kamiguchi, K., Schaefer, A.S., Long, K.E., Yamasaki, M., and Lemmon, V., The function of the cytoplasmic domain of the cell adhesion molecule L1 in normal and abnormal brain development. Frontiers of Neural Development, Keio Symposium, Vol 2, 241-248, 1999
Kamiguchi, K., and Lemmon, V. Signal-mediated sorting of the cell adhesion molecule L1: role of its cytoplasmic domain. Frontiers of Neural Development, Keio Symposium, Vol 2, 255-260, 1999
Yamasaki, M., and Lemmon, V., Mutations in L1CAM correlate with severity of developmental defects in brain development, Frontiers of Neural Development, Keio Symposium Vol 2, 273-275, 1999
Williams, S., Leventhal, C., Lemmon, V., Nedergaard, M., Goldman, S.A. Estrogen promotes the initial migration and inception of NgCAM-dependent calcium-signaling by new neurons of the adult songbird brain. Mol. Cell Neurosci. 13:41-55, 1999
Esch, T., Lemmon, V., Banker, G. Local presentation of substrate molecules directs axon specification by cultured hippocampal neurons. J. Neurosci. 19:6417-6326, 1999
Haney, C.A., Sahenk, Z., Li, C., Lemmon, V.P., Roder, J., Trapp, B.D. Heterophilic binding of L1 on unmyelinated sensory axons mediates Schwann cell adhesion and is required for axonal survival. J. Cell Biol. 146:1173-1183, 1999
Schaefer, A.W., Kamiguchi, H., Wong, E.V., Beach, C.M., Landreth, G., and Lemmon, V. Activation of the MAPK Signal Cascade by the Neural Cell Adhesion Molecule L1 Requires L1 Internalization. J. Biol. Chem. 274:37965-37973., 1999
Nayeem, N., Steve Silletti, S., Xiu-Ming Yang, X.-M., Vance A. Lemmon, V.P., Reisfeld, R.A., Stallcup, W.B., Montgomery, A.M.P. A potential role for the plasmin(ogen) system in the posttranslational cleavage of the neural cell adhesion molecule L1'. J. Cell Science 112:4739-4749, 1999
Kamiguchi, H., Hlavin, M.L., Yamasaki, M., Lemmon, V. Adhesion molecules and inherited diseases of the nervous system. Annual Reviews of Neuroscience, 1998, 21:97-125.
Fransen E, D'Hooge R, Van Camp G, Verhoye M, Sijbers J, Reyniers E, Soriano P, Kamiguchi H, Willemsen R, Koekkoek SKE, Zeeuw CI, Deyn PPD, Van der Linden A, Lemmon V, Kooy RF, Willems PJ. L1 knockout mice show dilated ventricles, vermis hypoplasia and impaired exploration patterns. Human Molecular Genetics. 1998;7(6):999-1009.
Kamiguchi, H., Lemmon, V. A neuronal form of the cell adhesion molecule L1 contains a tyrosine-based signal required for sorting to the axonal growth cone. J. Neurosci., 18:3749-3756, 1998
Kamiguchi, H., Long, K.E., Pendergast, M., Schaefer, A.W., Rapoport, I, Kirchhausen, T., Lemmon, V. The Neural Cell Adhesion Molecule L1 Interacts with the AP-2 Adaptor and Is Endocytosed via the Clathrin-Mediated Pathway. J. Neurosci. 1998 18:5311-5321
Schaefer, A.. and Lemmon, V. Signal transduction, neurite growth and IG superfamily adhesion molecules in the vertebrate nervous system. Ig superfamily molecules in the nervous system, Ed. P. Sonderegger, Harwood Academic Pub. 1998
1996-1997
Drazba, J., Liljelund, P., Smith, C., Payne, R., Lemmon, V. Growth cone interactions with purified cell and substrate adhesion molecules visualized by interference reflection microscopy. Dev. Brain Res., 100:183-197, 1997
Yamasaki M, Thompson P, Lemmon V. CRASH Syndrome: Mutations in L1CAM Correlate with Severity of the Disease. Neuropediatrics. 1997; 28:175-178.
Kamiguchi, H., Lemmon, V., The neural cell adhesion molecule L1: signaling pathways and growth cone motility. J. Neurosci. Res., 49:1-8, 1997
Burden-Gulley, S.M., Pendergast, M. Lemmon, V., The role of the cell adhesion molecule L1 in axonal extension, growth cone motility and signal transduction, Cell and Tissue Res. 290:415-422, 1997
Goldman, S.A., Williams, S., Barami, K., Lemmon, V., Nedergaard, M. Transient coupling of Ng-CAM expression to Ng-CAM-dependent calcium-signalling during migration of new neurons in the adult songbird forebrain. Mol. and Cell Neurosci. 7: 29-45, 1996
Wong, E.V., Schaefer, A.W., Landreth, G., Lemmon, V. Casein kinase II phosphorylates the neural cell adhesion molecule L1, J. Neurochem., 66:779-786, 1996
Montgomery, A., Becker, J.C., Siu, C.-H., Lemmon, V.P., Cheresh, D.A., Pancock, J.D., Zhao, X., Reisfeld, R.A. Human neural cell adhesion molecule L1 and rat homologue NILE are ligands for integrin alphaVbeta3, J. Cell Biol. 132:475-485, 1996
Burden-Gulley, S.M., Lemmon, V. L1/8D9, N-cadherin and laminin induce distinct distribution patterns of cytoskeletal elements in growth cones. Cell Motility and the Cytoskeleton 35:1-23, 1996
Payne, H.R., Hemperly, J.J., Lemmon, V. N-cadherin expression and function in cultured oligodendrocytes. Dev. Br. Res. 97:9-15, 1996
Wong, E.V., Schaefer, A.W., Landreth, G. and Lemmon, V. Involvement of p90rsk in neurite outgrowth mediated by the cell adhesion molecule L1. J. Biol. Chem. 271:18217-18233, 1996
1990-1995
Ring, C., Lemmon, V., Halfter, W. Two chondroitin sulfate proteoglycans differentially expressed in the developing chick visual system. Dev. Biol. 168:11-27, 1995
Burden-Gulley, S.M., Payne, H.R., Lemmon, V. Growth cones are actively influenced by substrate-bound adhesion molecules. J. Neurosci., 15:4370-4381, 1995
Wong, E.V., Kenwrick, S, Willems, and V. Lemmon. Mutations in the cell adhesion molecule L1 cause mental retardation. Trends in Neuroscience. 18:168-172
Brittis, P.A., Lemmon, V., Rutishauser, U., Silver, J. Cell adhesion molecules in concert with repulsive molecules govern intraretinal axon guidance: a time lapse study of the living retina. Mol and Cell Neurobiology, 6:433-449, 1995
Fransen, E., Lemmon, V., Van Camp, G., Vits, L., Coucke, P., Willems, P.J. CRASH syndrome: a clinical spectrum of corpus callosum hypoplasia, retardation, adducted thumbs, spastic paraparesis and hydrocephalus due to mutations in one single gene, L1. European Journal of Human Genetics. 3:273-284, 1995
Willbold, E., Reinicke, M., Lance-Jones, C., Lagenaur, C., Lemmon, V., Layer, P.G. Muller glia stabilizes cell columns during retinal development: lateral cell migration but not neuropil growth is inhibited in mixed chick-quail retinospheroids. Eur. J. Neurosci. 7:2277-2284, 1995
Wong EV, Cheng G, Payne HR, Lemmon V. The cytoplasmic domain of the cell adhesion molecule L1 is not required for homophilic adhesion. Neuroscience Letters. 1995; 200:155-158.
Lemmon, V. "How to Talk to Children" in : How-To Book; a primer on working with schools, Soc. for Neuroscience, Committee on Neuroscience Literacy, 1992-1995, editor 1994 and 1995
Seminars in Developmental Biology: 6:2 Cell Interaction Molecules in Development, Guest Editors: U. Rutishauser and V. Lemmon 1995
Barami, K., Kirschenbaum, B., Lemmon, V., Goldman, S. N-cadherin and NgCAM/8D9 are involved serially in the migration of newly generated neurons into the adult song bird brain. Neuron, 13:567-582, 1994
Sloan, S.F., Lemmon, V. and Koenig, E. Monoclonal antibody 8A2 induced retraction is mediated by protein phosphorylation in goldfish retinal ganglion cell axons. Dev. Biol., 156:230-242, 1993
Goldman, S.A., Lemmon, V., and Chin, S.S.-M. Migration of newly generated neurons upon ependymally-derived radial guide cells in explant cultures of the adult avian forebrain. Glia, 8:150-160, 1993
Payne, H.R., and Lemmon V. Glial cells of the O-2A lineage bind preferentially to N-cadherin and develop distinct morphologies. Dev. Biol. 159:595-607, 1993
Barry, C.P., Xie, J., Lemmon, V., and Young, A.P. Molecular characterization of a multipromoter gene encoding a chicken filamin protein. J. Biological Chemistry 268:25577-25586, 1993
Lemmon, V., Burden, S.M., Payne, H.R., Elmslie, G.J. and Hlavin, M.L. Neurite growth on different substrates: permissive versus instructive influences and the role of adhesive strength. J. Neuroscience, 12:818-826, 1992 My only experiment to make it into a text book. :-)
Payne, H.R., Burden, S. and Lemmon, V. Modulation of growth cone morphology by substrate bound cell adhesion molecules. Cell Motility and the Cytoskeleton, 21:65-73, 1992
Sloan, S.F., Lemmon, V. and Koenig, E. Characterization of the retraction response of goldfish axons triggered by monoclonal antibody 8A2 in vitro. Cell Motility and the Cytoskeleton, 23:279-301, 1992
Drazba, J., Pierce, M., and Lemmon, V. Studies of the developing chick retina using monoclonal antibody 8A2 that recognizes a novel set of gangliosides. Dev. Biol. 145: 154-163, 1991
Hlavin, M.L. and Lemmon, V. Molecular structure and functional testing of human L1: an interspecies comparison. Genomics, 11, 416-423, 1991 First publication of human L1CAM sequence.
Letourneau, P.C., Roche, F.K., Shattuck, T.A., Lemmon, V., and Takeichi, M. Interactions of Schwann cells with neurites and with other Schwann cells involve the calcium-dependent adhesion molecule, N-cadherin. J. Neurobiology, 22:707-720, 1991.
Cervello, M., Lemmon, V., Landreth, G., and Rutishauser, U. Phosphorylation-dependent regulation of neurite fasciculation. Proc. Natl. Acad. Sci., USA, 88:10548-10552, 1991
Letourneau, P.C., Shattuck, T.A., Roche, F., Takeichi, M., and Lemmon, V., Nerve growth cone migration onto Schwann cells involves the calcium-dependent adhesion molecule, N-cadherin. Dev. Bio. 138:430-442, 1990
Drazba, J. and Lemmon, V., The role of cell adhesion molecules in neurite outgrowth on Muller cells. Dev. Bio. 138:82-93, 1990
Snow, D.M., Lemmon, V., Carrino, D.A., Caplan, A.I., and Silver, J. Sulfated proteoglycans present in astroglial barriers during development in vivo inhibit neurite outgrowth in vitro. Exp. Neurol. 109:111-130, 1990
1977-1989
Lemmon, V., Farr, K., Lagenaur, C. L1 mediated axon outgrowth occurs via a homophilic binding mechanism. Neuron, 2:1597-1603, 1989 Cool assay to demonstrate homophilic binding in neurite growth.
Lemmon, S.K., Lemmon, V.P., and Jones, E.W. Characterization of yeast clathrin and anti-clathrin heavy chain monoclonal antibodies. J. Cellular Biochem. 36: 329-340, 1988
Lemmon, V., Farr, K. and Lagenaur, C. The role of a cell adhesion molecule in neurite outgrowth and regeneration. In: Cell Interactions in Visual Development. S.R. Hilger and J.B. Sheffield (Eds.), Springer Verlag, 1988
Lemmon, V. A monoclonal antibody that binds to the surface of photoreceptors. Dev. Brain Res. 39:117-123, 1988.
Risau, W. and Lemmon, V. Changes in the vascular extracellular matrix during embryonic vasculogenesis and angiogenesis. Dev. Bio. 125:441-450, 1988
Hyndman, A.G. and Lemmon, V. Neurons and glia in purified retinal cultures identified by monoclonal antibodies to intermediate filaments. Neurosci. Lett. 75:121-126, 1987
Lagenaur, C. and Lemmon, V. A L1-like molecule, the 8D9 antigen, is a potent substrate for neurite extension. Proc. Natl. Acad. Sci., USA 84:7753-7757, 1987 First purified CAM to promote axon growth. Introduction of the use of dissolved nitrocellulose to create substrates for cell culture.
Lemmon, V. The localization of a filamin-like protein in glia of the chick central nervous system. J. Neurosci. 6:43-51, 1986
Lemmon, V. A monoclonal antibody that binds to cones. Invest. Ophthalmol. and Vis. Sci. 27:831-836, 1986
Lemmon, V. and McLoon, S. The appearance of an L1 like molecule in the chick primary visual pathway. J. Neurosci. 6:2987-2994, 1986
Lemmon, V. Monoclonal antibodies specific for glia in the chick central nervous system. Dev. Brain Res. 23:111-120, 1985
Lemmon, V. and Rieser, G. The development distribution of vimentin in the chick retina. Dev. Brain Res. 11:191-198, 1983.
Post-Doc
Lemmon, V., Staros, E.B., Perry, H.E., and Gottlieb, D.I. A monoclonal antibody which binds to the surface of chick brain cells and myotubes: Cell selectivity and properties of the antigen. Dev. Brain Res. 255:349-360, 1982.
Lemmon, V. and Gottlieb, D.I. Monoclonal antibodies selective for the inner portion of the chick retina. J. Neurosci. 2:531-535, 1982
Simmons, P.A., Lemmon, V., and Pearlman, A.L. Afferent and efferent connections of the striate and extrastriate visual cortex of the normal and reeler mouse. .J. Comp. Neurol. 211:295-308, 1982
Lemmon, V. and Gottlieb, D.I. Techniques for the production of monoclonal antibodies against the chick retina. In: Syllabus of the 1981 short course of the Society for Neuroscience: New Approaches in Developmental Neurobiology.
Lemmon, V. and Pearlman, A.L. Does laminar position determine the receptive field properties of cortical neurons: A study of corticotectal cells in area 17 of the normal mouse and reeler mouse. J. Neurosci. 1:83-93, 1981
Grad School
Anderson, K.V. and Lemmon, V. The effects of constant light on visually guided behavior. In: The Effects of Constant Light on Visual Processes. T.P. Williams and B.N. Baker (Eds.), Plenum Press, 1980.
Anderson, K.V., Lemmon, V., and O'Steen, W.K. Neurophysiological properties of visual neurons in rats with light damaged retina. In: The Effects of Constant Light on Visual Processes. T.P. Williams and B.N. Baker (Eds.), Plenum Press, 1980.
Lemmon, V. and Anderson, K.V. Behavioral correlates of constant light-induced retinal degeneration. Exp. Neurol. 63:34-49, 1979.
Lemmon, V. and Anderson, K.V. Central neurophysiologic correlates of constant light-induced retinal degeneration. Exp. Neurol. 63:50-75, 1979.
Anderson, K.V., Lemmon, V., and Rosing, H.S. Response properties of cells in the dorsal lateral geniculate nucleus of the albino rat. J. Neurosci. Res. 3:143-152, 1977.
